Changes in the Human Gut Microbiome during Dietary Supplementation with Modified Rice Bran Arabinoxylan Compound

This study investigated the effects of a modified rice bran arabinoxylan compound (RBAC) as dietary supplement on gut microbiota healthy adults. Ten volunteers supplemented their diet with 1 g RBAC for six weeks and 3 another weeks, three-week washout period. Faecal samples were collected every over 21 weeks. Microbiota from faecal profiled using 16S rRNA sequencing. Assessment alpha beta diversity was performed QIIME2 platform. The results revealed that not associated experimental phase, interventional period, dosage, or time. However, statistical significance participant detected in (p < 0.002) (weighted unifrac, p = 0.001) diversity. Explanatory factors, including lifestyle, significantly 0.05) 0.01) individual participants changed during Seven showed statistically significant taxonomic changes (ANCOM W ≥ 5). These classified four responders to supplementation, further two likely responders. In conclusion, microbiome is highly individualised modulated by supplement, dependent lifestyle intake.